The Gameday I run doesn’t involve hoteling people, so I would refer you to Willow Palecek on that.
We’re in one big room and usually have 6-7 tables of 4-7 people each, and I can tell you it gets loud. It’s been an issue for some folks.
We rely on volunteer GMs, and while we typically accommodate all the tables, I know that the burden ends up falling on a group of regulars, some of whom run two slots back-to-back. The BurningCon method is more daunting, but I think it better distributes the load, especially if you’re looking to fill 3+ days of three slots per day.
If you’re feeling overwhelmed, I’d consider scaling back. Do a house con with maybe 10-12 people and just shoot for Friday night through Sunday, like BurningCon and Forge Midwest. (Right now you’re trying to match GenCon in length, which seems like a lot to me. By Sunday at GenCon, I’m ready to hit the road. By Sunday at FMW, I’m sad to hit the road.)