I think Nathan Paoletta hit on something way up above, in that when I think about running/playing SF, I tend to think about “generic” games that I can use for SF. Since SF can be pretty much anything, I figure that I’ll start with the foundation for what the game is “about” — is it fighty? is it about Big Ideas™? is ti about just tooling around space? — and then look for a game that does that and then have lonely fun making it SF.

E.g., learning that The Expanse started as a d20 game makes me want to dust off my copies of d20 Modern and d20 Future. And I have fond memories of one glorious session of Star HERO I ran. And, PTA, heck yeah; pitch your SyFy show and go. And there’s always Burning Sands, which should be less brain-hurty than BE.

And I still hope to one day give Eclipse Phase a shot, as clunky as I understand it to be.