Mark Delsing I’m pretty sure it’s not impossible other than when constrained by certain very specific definitions.

The Mutant: Year Zero thing for example is fucking awesome. The Zone is procedurally generated, you can absolutely just wander around in it, and yet part of the procedure is to kick out bits and bobs of the campaign metaplot as you go. 

God damn it now I just want to run The One Ring under MYZ. Swap Rot for the Shadow and run.