I think I own all the .pdfs of the books, but have yet to read through all of them. Beautiful books. Great setting. Limited fan-base in my area for sci-fi rpgs.
I like the fact that the rules are non-exciting. It allows me to drive the story of the game and reflexively know the system without looking up all the rules. I think this also allows you to port the game to whatever system you want with minor work.
When porting to a new system, I think if you have a way to represent the different types of influence, a way to cover the various types of damage (mental, physical, etc.), and a way to track what the morphs add to a base character, you should be fine. I think all of these things could be done with various systems, just pick one you like, whether it be 5th ed., Cortex, Unisystem, or whatever they are calling WoD these days.
I’ve run one-shots of the game and enjoyed each one. I cut out some of the derived stats when I run the one-shots. While I think they are great ideas for a campaign (as you slowly go crazy), unless they are needed for one-shots, I cut them out. I may call out where we would normally use a specific stat I cut out to show an example in play, but otherwise, it’s too much for the player to absorb.